Terminliste
| 15.08.2021 | 1. runde | Bundesliga | Mainz | 1 - 0 | Leipzig | V sport1 | |
| 21.08.2021 | 2. runde | Bundesliga | Bochum | 2 - 0 | Mainz | Viaplay | |
| 28.08.2021 | 3. runde | Bundesliga | Mainz | 3 - 0 | Fürth | Viaplay | |
| 11.09.2021 | 4. runde | Bundesliga | Hoffenheim | 0 - 2 | Mainz | Viaplay | |
| 18.09.2021 | 5. runde | Bundesliga | Mainz | 0 - 0 | Freiburg | Viaplay | |
| 25.09.2021 | 6. runde | Bundesliga | Leverkusen | 1 - 0 | Mainz | Viaplay | |
| 03.10.2021 | 7. runde | Bundesliga | Mainz | 1 - 2 | Union Berlin | V sport1 | |
| 16.10.2021 | 8. runde | Bundesliga | Dortmund | 3 - 1 | Mainz | V sport1 | |
| 22.10.2021 | 9. runde | Bundesliga | Mainz | 4 - 1 | Augsburg | Viaplay | |
| 30.10.2021 | 10. runde | Bundesliga | Bielefeld | 1 - 2 | Mainz | Viaplay | |
| 05.11.2021 | 11. runde | Bundesliga | Mainz | 1 - 1 | M'gladbach | V sport1 | |
| 21.11.2021 | 12. runde | Bundesliga | Mainz | 1 - 1 | Köln | V sport1 | |
| 26.11.2021 | 13. runde | Bundesliga | Stuttgart | 2 - 1 | Mainz | V sport1 | |
| 04.12.2021 | 14. runde | Bundesliga | Mainz | 3 - 0 | Wolfsburg | Viaplay | |
| 11.12.2021 | 15. runde | Bundesliga | Bayern | 2 - 1 | Mainz | Viaplay | |
| 14.12.2021 | 16. runde | Bundesliga | Mainz | 4 - 0 | Hertha | V sport1 | |
| 18.12.2021 | 17. runde | Bundesliga | Frankfurt | 1 - 0 | Mainz | V sport1 | |
| 08.01.2022 | 18. runde | Bundesliga | Leipzig | 4 - 1 | Mainz | Viaplay | |
| 15.01.2022 | 19. runde | Bundesliga | Mainz | 1 - 0 | Bochum | Viaplay | |
| 22.01.2022 | 20. runde | Bundesliga | Fürth | 2 - 1 | Mainz | Viaplay | |
| 05.02.2022 | 21. runde | Bundesliga | Mainz | 2 - 0 | Hoffenheim | Viaplay | |
| 12.02.2022 | 22. runde | Bundesliga | Freiburg | 1 - 1 | Mainz | V sport+ | |
| 18.02.2022 | 23. runde | Bundesliga | Mainz | 3 - 2 | Leverkusen | V sport1 | |
| 26.02.2022 | 24. runde | Bundesliga | Union Berlin | 3 - 1 | Mainz | V sport1 | |
| 16.03.2022 | 25. runde | Bundesliga | Mainz | 0 - 1 | Dortmund | V sport1 | |
| 19.03.2022 | 27. runde | Bundesliga | Mainz | 4 - 0 | Bielefeld | Viaplay | |
| 03.04.2022 | 28. runde | Bundesliga | M'gladbach | 1 - 1 | Mainz | V sport1 | |
| 06.04.2022 | 26. runde | Bundesliga | Augsburg | 2 - 1 | Mainz | V sport1 | |
| 09.04.2022 | 29. runde | Bundesliga | Köln | 3 - 2 | Mainz | V sport+ | |
| 16.04.2022 | 30. runde | Bundesliga | Mainz | 0 - 0 | Stuttgart | V sport+ | |
| 22.04.2022 | 31. runde | Bundesliga | Wolfsburg | 5 - 0 | Mainz | V sport1 | |
| 30.04.2022 | 32. runde | Bundesliga | Mainz | 3 - 1 | Bayern | V sport+ | |
| 07.05.2022 | 33. runde | Bundesliga | Hertha | 1 - 2 | Mainz | V sport2 | |
| 14.05.2022 | 34. runde | Bundesliga | Mainz | 2 - 2 | Frankfurt | Viaplay |
Spillerstall
| Nr. | Navn | Posisjon | Alder | K | M |  |
 |
||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Finn Dahmen | Keeper | 23 | 2 | - | - | - | ||
| 27 | Robin Zentner | Keeper | 27 | 32 | - | - | 1 | ||
| 3 | Aarón | Forsvar | 24 | 28 | 1 | - | 7 | ||
| 4 | Jerry St. Juste | Forsvar | 25 | 8 | 1 | - | - | ||
| 15 | Luca Kilian | Forsvar | 22 | 1 | - | - | - | ||
| 16 | Stefan Bell | Forsvar | 30 | 33 | 2 | - | 9 | ||
| 18 | Daniel Brosinski | Forsvar | 38 | 11 | - | - | - | ||
| 19 | Moussa Niakhate | Forsvar | 25 | 30 | 4 | - | 1 | ||
| 23 | Anderson Lucoqui | Forsvar | 24 | 13 | 1 | - | 2 | ||
| 30 | Silvan Widmer | Forsvar | 28 | 33 | 4 | - | 1 | ||
| 34 | David Nemeth | Forsvar | 20 | 6 | - | - | - | ||
| 42 | Alexander Hack | Forsvar | 28 | 28 | 3 | 1 | 6 | ||
| 6 | Anton Stach | Midtbane | 23 | 29 | 1 | - | 6 | ||
| 7 | Lee Jae-sung | Midtbane | 29 | 27 | 4 | - | 3 | ||
| 8 | Leandro Barreiro Martins | Midtbane | 21 | 31 | 1 | - | 3 | ||
| 22 | Kevin Stöger | Midtbane | 28 | 23 | 1 | - | 3 | ||
| 24 | Merveille Papela | Midtbane | 20 | 5 | - | - | - | ||
| 25 | Niklas Tauer | Midtbane | 20 | 11 | - | 1 | 1 | ||
| 31 | Dominik Kohr | Midtbane | 27 | 22 | - | 2 | 6 | ||
| 35 | Stephan Fürstner | Midtbane | 34 | 1 | - | - | - | ||
| 36 | Kaito Mizuta | Midtbane | 21 | 0 | - | - | - | ||
| 43 | Romario Rösch | Midtbane | 22 | 1 | - | - | - | ||
| 5 | Jean-Paul Boëtius | Angrep | 27 | 33 | 2 | - | 3 | ||
| 9 | Karim Onisiwo | Angrep | 29 | 31 | 5 | - | - | ||
| 11 | Marcus Ingvartsen | Angrep | 25 | 26 | 6 | - | 2 | ||
| 26 | Paul Nebel | Angrep | 19 | 10 | - | - | 3 | ||
| 28 | Ádám Szalai | Angrep | 34 | 12 | 1 | - | 1 | ||
| 29 | Jonathan Burkardt | Angrep | 21 | 34 | 11 | - | - | ||
| 37 | Delano Burgzorg | Angrep | 23 | 3 | 1 | - | - | ||
| 32 | Lasse Riess | 20 | 0 | - | - | - | |||
| 37 | Timothe Rupil | 18 | 0 | - | - | - | |||
| 39 | Ben Bobzien | 18 | 0 | - | - | - | |||
| 41 | Eniss Shabani | 18 | 0 | - | - | - | |||
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Forkortelser:
K: Kamper
M: Mål
Røde kort
Gule kort
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